Treatment Explained

After a thorough medical history and assessment of the area(s) to be treated your doctor will be able to give you a clear answer as to whether wrinkle relaxing injections can resolve the problem or a combination of treatments (e.g. fillers, medical microneedling, fat transfer, platelet rich plasma injections, blepharoplasty etc) should be advised for optimal results.

The treatment consists of a series of injections of a carefully reconstituted solution into the underlying muscle. Your doctor will accurately calculate the number of units needed per injection site and will then use a tiny sterile needle to inject where required.

Following the treatment you can return to work or your daily routine and activities provided that you avoid exercise, heavy lifting, saunas, excessive forward bending and rubbing of the treated area(s) for 24 hours. Clear post injection instructions will be given in writing after your treatment.

Depending on the type of neurotoxin used results will start usually showing after the first 48-72 hours peaking between 10-14 days. Muscle weakness or paralysis after the initial injection lasts between 4 and 6 months for most patients.

Treatment intervals should not be more frequent than every three months due to a remote risk of formation of neutralizing antibodies reducing the effectiveness of the muscle relaxing treatment by inactivating the biological activity of the toxin.


Muscle relaxing injections should not be used in the following cases:

  • During pregnancy or breast feeding.
  • In individuals with known hypersensitivity to botulinum toxin A or to any of the excipients (e.g. human albumin).
  • In the presence of infection or severe inflammation at the injection sites.
  • Disorders of the neuromuscular junction
    • Myasthenia gravis
    • Lambert-Eaton myasthenic syndrome
    • Multiple sclerosis
    • Myopathies
  • Aminoglycoside antibiotic therapy

Wrinkle relaxing injections should not be used concurrently with ablative treatments such laser skin resurfacing, microdermabrasion, chemical peels.

Side effects

In the vast majority of our clients there have been no or minimal side effects such as temporary bruising or redness. Please inform your doctor if you are on blood thinning medication. Arnica or Vitamin K based creams can help those prone to bruising. It is also advisable not to use Aspirin or any other non-steroidal anti-inflammatory drugs such as Ibuprofen for at least three days prior to your treatment in order to minimize any potential bruising.

More rare side effects include:

  • Headache
  • Injection site reactions (e.g. redness, irritation, discomfort, itching)
  • Eyelid drooping - adrenoreceptor agonist eye drops can help reverse this complication
  • Brow ptosis
  • Dry eye
  • Diffusion of product injected to adjacent muscles

However all side effects are transient and some of them can be avoided if you stick to your post treatment instructions.

Is there any alternative treatment to wrinkle relaxing injections?

In the rare case of hypersensitivity to muscle relaxing injections alternative treatments with Argireline and Leuphasyl could be used. For more information please download Dr Sotirios Foutsizoglou’s relevant articles.